Exercise, mitochondrial biogenesis and disuse-induced atrophy
نویسندگان
چکیده
منابع مشابه
Mitochondrial signaling contributes to disuse muscle atrophy.
It is well established that long durations of bed rest, limb immobilization, or reduced activity in respiratory muscles during mechanical ventilation results in skeletal muscle atrophy in humans and other animals. The idea that mitochondrial damage/dysfunction contributes to disuse muscle atrophy originated over 40 years ago. These early studies were largely descriptive and did not provide uneq...
متن کاملMitochondrial pathways in sarcopenia of aging and disuse muscle atrophy.
Muscle loss during aging and disuse is a highly prevalent and disabling condition, but knowledge about cellular pathways mediating muscle atrophy is still limited. Given the postmitotic nature of skeletal myocytes, the maintenance of cellular homeostasis relies on the efficiency of cellular quality control mechanisms. In this scenario, alterations in mitochondrial function are considered a majo...
متن کاملFunctional and morphological effects of resistance exercise on disuse-induced skeletal muscle atrophy.
Abstract quality of life. Since there is no currently effective and safe treatment available for skeletal muscle atrophy, the search for new alternatives is necessary. Resistance exercise (RE) seems to be an important tool in the treatment of disuse-induced skeletal muscle atrophy by promoting positive functional (strength and power) and structural (hypertrophy and phenotypic changes) adaptive ...
متن کاملRole of calcineurin in exercise-induced mitochondrial biogenesis.
Raising cytosolic Ca2+ induces an increase in mitochondrial biogenesis in myotubes. This phenomenon mimics the adaptive responses of skeletal muscle to exercise. It has been hypothesized that increases in cytosolic Ca2+ during motor nerve activity stimulate mitochondrial biogenesis by activating calcineurin. Overexpression of constitutively active calcineurin increases expression of peroxisome ...
متن کاملCan endurance exercise preconditioning prevention disuse muscle atrophy?
Emerging evidence suggests that exercise training can provide a level of protection against disuse muscle atrophy. Endurance exercise training imposes oxidative, metabolic, and heat stress on skeletal muscle which activates a variety of cellular signaling pathways that ultimately leads to the increased expression of proteins that have been demonstrated to protect muscle from inactivity -induced...
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ژورنال
عنوان ژورنال: Turkish Journal of Sports Medicine
سال: 2021
ISSN: 1300-0551,2587-1498
DOI: 10.47447/tjsm.0491